The DMC is closely associated with the University’s School of Marine Sciences (SMS). Eight SMS faculty are in residence at the DMC, including the Director. Focal research themes include aquaculture and marine fisheries; biogeochemistry and microbial ecology; conservation science and policy; invertebrate biology and biodiversity; and plankton ecology and oceanography.

Throughout the year, visiting researchers and students from throughout the University of Maine System, the state and the nation use the DMC as a platform for investigating a wide range of terrestrial, coastal marine, and estuarine themes. The DMC is one of the core research sites for the NSF-funded Maine-eDNA program, and also contributes to other marine monitoring networks.